How did Mariani, Freud, and Koller popularize the use of cocaine?

1. If an older adult has less protein in the blood than a younger person, how would you adjust the dose of a drug that has high protein binding?

2. How might two drugs interact with each other through actions on the CYP450 enzyme system?

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3. How did Mariani, Freud, and Koller popularize the use of cocaine?

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